Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta)

被引：1

作者：

Goldschmidt, B. ^{[1
]}

Calado, M. I. Z. ^{[1
]}

Resende, F. C. ^{[1
]}

Caldas, R. M. ^{[2
]}

Pinto, L. W. ^{[3
]}

Lopes, C. A. A. ^{[1
]}

Franca, F. G. O. ^{[4
]}

Meireles, B. S. ^{[1
]}

Souza, I. V. ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz FIOCRUZ, ICTB, Serv Criacao Primatas Nao Humanos, Ave Brasil, Rio De Janeiro, Brazil

[2] Fundacao Oswaldo Cruz, Inst Nacl Infectol Evandro Chagas, Lab Pesquisa Clin Dermatozoonoses Anim Domest, Rio De Janeiro, RJ, Brazil

[3] Inst Nacl Canc, Div Patol, Rio De Janeiro, RJ, Brazil

[4] Fundacao Oswaldo Cruz, Nacl Infectol Evandro Chagas, Setor Radiol, Rio De Janeiro, RJ, Brazil

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 2017年 / 46卷 / 02期

关键词：

bone cancer; chromosomes; non-human primate; osteosarcoma; DNA ANALYSIS; CHROMOSOME;

D O I：

10.1111/jmp.12254

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Osteosarcoma (OS) is the most common type of bone cancer, especially in young. Telangiectatic osteosarcoma (TO) is a rare variant of OS, and hence, its occurrence, presentation, and prognosis are poorly understood. A 4-year-old female rhesus monkey presenting lameness and swelling was examined for a mass on the right humerus. Radiography revealed fracture and disorganized structure of bone tissue. Histopathological examination revealed malignant neoplasm composed of anaplastic osteoblasts, which invaded the bone marrow and surrounded blood-filled cysts in the epiphysis and diaphysis forming septa. Cytogenetic analysis showed aneuploid cells, supernumerary AgNORs, and a marker fragment. The neoplasm was diagnosed as TO. To our knowledge, the occurrence of TO and its cytogenetic analysis were reported for the first time in non-human primates.

引用

页码：51 / 55

页数：5

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