Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats

被引：61
作者：
Abrahám, CS
Harada, N
Deli, MA
Niwa, M
机构：
[1] Nagasaki Univ, Sch Med, Dept Pharmacol 1, Nagasaki 8528523, Japan
[2] Nagasaki Univ, Sch Med, Dept Anesthesiol, Nagasaki 852, Japan
[3] Hungarian Acad Sci, Biol Res Ctr, Inst Biophys, Mol Neurobiol Lab, H-6701 Szeged, Hungary
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 2002年 / 22卷 / 04期
基金：
日本学术振兴会;
关键词：
blood-brain barrier permeability; cerebral ischemia-reperfusion; Evan's blue-albumin; sodium fluorescein; stroke-prone spontaneously hypertensive rat;
D O I：
10.1023/A:1021067822435
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
1. The aim of the present study was to reveal the effect of transient forebrain ischemia on the regional and temporal changes in the permeability of the blood-brain barrier (BBB) permeability for sodium fluorescein (MW: 376 Da) and Evan's blue-labeled albumin (MW: 67 kDa) in stroke-prone spontaneously hypertensive rats (SHRSP). 2. BBB permeability was significantly higher in the brain regions of 16-week-old control SHRSP than those in age-matched normotensive Wistar-Kyoto rats. 3. Transient forebrain ischemia evoked by 10-min bilateral carotid occlusion increased the permeability of the BBB for albumin, but not for sodium fluorescein, after 6 and 24 h of reperfusion in brain regions of SHRSP. 4. Extravasation of serum macromolecules may contribute to neuronal loss and development of hypertensive encephalopathy in SHRSP.
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收藏
页码：455 / 462
页数：8
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