Enantioselective Synthesis of Unsymmetrical Triarylmethanes by Chiral Bronsted Acids

被引：154
作者：
Sun, Feng-Lai [1 ]
Zheng, Xiao-Jian [1 ]
Gu, Qing [1 ]
He, Qing-Li [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Chiral Bronsted acids; Enantioselectivity; Friedel-Crafts reaction; Indole; Organocatalysis; FRIEDEL-CRAFTS REACTION; ELECTRON-RICH ARENES; ARYLBORONIC ACIDS; PHOSPHORIC-ACIDS; ALKYLATION; INDOLES; IMINES; DERIVATIVES; CATALYST; ACCESS;
D O I：
10.1002/ejoc.200901164
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chiral Bronsted acid catalyzed Friedel-Crafts alkylation of electron-rich arenes with (3-indolyl)methanamines has been realized to provide an efficient synthesis of enantioenriched unsymmetrical triarylmethanes. With 5 mol-% of a newly developed chiral phosphoric acid, the enantioenriched unsymmetrical triarylmethanes were obtained in excellent yields with up to 91 % ee.
引用
收藏
页码：47 / 50
页数：4
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