Enantioselective Synthesis of Unsymmetrical Triarylmethanes by Chiral Bronsted Acids

被引：154

作者：

Sun, Feng-Lai ^{[1
]}

Zheng, Xiao-Jian ^{[1
]}

Gu, Qing ^{[1
]}

He, Qing-Li ^{[1
]}

You, Shu-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Chiral Bronsted acids; Enantioselectivity; Friedel-Crafts reaction; Indole; Organocatalysis; FRIEDEL-CRAFTS REACTION; ELECTRON-RICH ARENES; ARYLBORONIC ACIDS; PHOSPHORIC-ACIDS; ALKYLATION; INDOLES; IMINES; DERIVATIVES; CATALYST; ACCESS;

D O I：

10.1002/ejoc.200901164

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral Bronsted acid catalyzed Friedel-Crafts alkylation of electron-rich arenes with (3-indolyl)methanamines has been realized to provide an efficient synthesis of enantioenriched unsymmetrical triarylmethanes. With 5 mol-% of a newly developed chiral phosphoric acid, the enantioenriched unsymmetrical triarylmethanes were obtained in excellent yields with up to 91 % ee.

引用

页码：47 / 50

页数：4

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