Clinical neuroprosthetics: Today and tomorrow

被引：15
|
作者：
Lee, Morgan B. [1 ,2 ]
Kramer, Daniel R. [1 ,2 ]
Peng, Terrance [1 ,2 ]
Barbaro, Michael F. [1 ,2 ]
Liu, Charles Y. [1 ,2 ,4 ]
Kellis, Spencer [1 ,2 ,3 ,4 ]
Lee, Brian [1 ,2 ,4 ]
机构：
[1] Univ Southern Calif, Dept Neurol Surg, Keck Sch Med USC, Los Angeles, CA USA
[2] Keck Sch Med USC, USC Neurorestorat Ctr, Los Angeles, CA USA
[3] CALTECH, T&C Chen Brain Machine Interface Ctr, Pasadena, CA 91125 USA
[4] CALTECH, Dept Biol & Biol Engn, Pasadena, CA 91125 USA
来源：
JOURNAL OF CLINICAL NEUROSCIENCE | 2019年 / 68卷
基金：
美国国家卫生研究院;
关键词：
DEEP BRAIN-STIMULATION; VAGUS NERVE-STIMULATION; RESPONSIVE CORTICAL STIMULATION; RANDOMIZED CONTROLLED-TRIAL; PARKINSONS-DISEASE; PROSTHETIC DEVICES; ICTAL TACHYCARDIA; EPILEPSY; NEUROMODULATION; REDUCTION;
D O I：
10.1016/j.jocn.2019.07.056
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Implantable neurostimulation devices provide a direct therapeutic link to the nervous system and can be considered brain-computer interfaces (BCI). Under this definition, BCI are not simply science fiction, they are part of existing neurosurgical practice. Clinical BCI are standard of care for historically difficult to treat neurological disorders. These systems target the central and peripheral nervous system and include Vagus Nerve Stimulation, Responsive Neurostimulation, and Deep Brain Stimulation. Recent advances in clinical BCI have focused on creating "closed-loop" systems. These systems rely on biomarker feedback and promise individualized therapy with optimal stimulation delivery and minimal side effects. Success of clinical BCI has paralleled research efforts to create BCI that restore upper extremity motor and sensory function to patients. Efforts to develop closed loop motor/sensory BO is linked to the successes of today's clinical BCI. (C) 2019 Elsevier Ltd. All rights reserved.
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页码：13 / 19
页数：7
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