Cytokines and pregnancy: Potential regulation by histone deacetylases

被引：24
作者：
Munro, Sheryl K. [1 ]
Balakrishnan, Biju [1 ]
Lissaman, Abbey C. [1 ]
Gujral, Palak [1 ]
Ponnampalam, Anna P. [1 ,2 ,3 ]
机构：
[1] Univ Auckland, Liggins Inst, Auckland, New Zealand
[2] Univ Auckland, Fac Med & Hlth Sci, Dept Physiol, Auckland, New Zealand
[3] Univ Auckland, Fac Med & Hlth Sci, Dept Obstet & Gynaecol, Auckland, New Zealand
来源：
MOLECULAR REPRODUCTION AND DEVELOPMENT | 2021年 / 88卷 / 05期
关键词：
cytokines; histone acetylation; histone deacetylases; pregnancy; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; TOLL-LIKE RECEPTOR; PROINFLAMMATORY GENE-EXPRESSION; TRANSFORMING-GROWTH-FACTOR; HUMAN PLACENTAL TISSUES; FACTOR-ALPHA; TNF-ALPHA; PRETERM LABOR;
D O I：
10.1002/mrd.23430
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cytokines are important regulators of pregnancy and parturition. Aberrant expression of proinflammatory cytokines during pregnancy contributes towards preterm labor, pre-eclampsia, and gestational diabetes mellitus. The regulation of cytokine expression in human cells is highly complex, involving interactions between environment, transcription factors, and feedback mechanisms. Recent developments in epigenetic research have made tremendous advancements in exploring histone modifications as a key epigenetic regulator of cytokine expression and the effect of their signaling molecules on various organ systems in the human body. Histone acetylation and subsequent deacetylation by histone deacetylases (HDACs) are major epigenetic regulators of protein expression in the human body. The expression of various proinflammatory cytokines, their role in normal and abnormal pregnancy, and their epigenetic regulation via HDACs will be discussed in this review.
引用
收藏
页码：321 / 337
页数：17
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