Hyaluronic acid-amorphous calcium phosphate nanoparticles for drug delivery and anticancer

被引：1
|
作者：
Li, Min [1 ,2 ]
Niu, Baolong [1 ,2 ,3 ]
Guo, Xia [1 ,2 ]
Rao, Chaohui [1 ,2 ]
Li, Wenfeng [1 ,2 ]
机构：
[1] Taiyuan Univ Technol, Minist Educ, Key Lab Interface Sci & Engn Adv Mat, Taiyuan, Peoples R China
[2] Taiyuan Univ Technol, Coll Mat Sci & Engn, Taiyuan 030024, Peoples R China
[3] Shanxi Med Univ, Sch Basic Med Sci, Taiyuan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2022年 / 71卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Amorphous calcium phosphate; hyaluronic acid; (NaPO3)(6); curcumin; drug release; CARRIERS; RELEASE;
D O I：
10.1080/00914037.2020.1860982
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Although amorphous calcium phosphate has been a mature research object in the medicine field, its application in drug carriers remains restricted due to its easy agglomeration and poor dispersion stability. Accordingly, the ACP was modified with hyaluronic acid (HA) and hexametaphosphate ((NaPO3)(6)), the amorphous structure can be kept for more than 3 months based on HA stabilizers, the dispersion can be maintained for about one month owing to the (NaPO3)(6). In vitro, the Cur-HA-ACP-(NaPO3)(6) nanoparticles showed high drug loading, good pH response performance and favorable antitumor ability. Overall, Cur loaded HA-ACP nanoparticles exhibited a great potential for anticancer chemotherapeutics.
引用
收藏
页码：561 / 567
页数：7
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