Associations between CB-153 and p,p'-DDE and hormone levels in serum in middle-aged and elderly men

被引:45
作者
Rylander, Lars
Wallin, Ewa
Jonssson, Bo A. G.
Stridsberg, Mats
Erfurth, Eva Marie
Hagmar, Lars [1 ]
机构
[1] Lund Univ, Univ Lund Hosp, Dept Lab Med, Div Occupat & Environm Med & Psychiat Epidemiol, SE-22185 Lund, Sweden
[2] Univ Uppsala Hosp, Dept Med Sci, Uppsala, Sweden
[3] Univ Lund Hosp, Dept Internal Med, Div Endocrinol & Diabetol, S-22185 Lund, Sweden
基金
瑞典研究理事会;
关键词
epidemiology; estradiol; FSH; gonadotropins; LH; testosterone; thyroxin; TSH;
D O I
10.1016/j.chemosphere.2006.02.012
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Animal and epidemiologic data indicate that exposure to persistent organochlorine pollutants (POPs) may disrupt the hypothalamus-pituitary-thyroid (HPT) and the hypothalamus-pituitary-gonadal (HPG) axes. We have assessed whether the POP-biomarkers 2,2'4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethene (p,p'-DDE) affect thyrotropin (TSH), thyroid hormones, gonadotropins or sex hormone concentrations in men. Methods: Lipid adjusted serum concentrations of CB-153, and p,p'-DDE, were determined in 196 men (median age 59 years, range 48-82). Hormone analyses in serum were performed with immunoassays. The effect of CB-153 and p,p'-DDE (as continuous or categorized variables) were evaluated by linear regression models, adjusting for potential confounders. Results: There was a significant positive association between p,p'-DDE and TSH. An increase of 100 ng/g lipid of p,p'-DDE corresponded to an increase of 0.03 mU/l (95% Confidence Interval (CI) 0.01, 0.05) in TSH level. The explanatory value (R 2) of the multi-variate model was only 7%. Moreover, there was a significant negative association between p,p'-DDE and estradiol. An increase of 100 ng/g lipid of p,p'-DDE corresponded to a decrease of 0.57 pmol/l (95% CI -1.0, -0.12) in estradiol level. The R-2-value was only 4%. No associations were observed between any of the POP biomarkers and the other hormones. Conclusions: The positive association between p,p'-DDE and TSH and the negative association between p,p'-DDE and estradiol, among middle-aged and elderly men, were not accompanied by associations between the POP-markers and thyroxin, testosterone, and gonadotropins, respectively. The results gives some additional support for that POP exposure may affect HPT- and HPG-axes also in humans, but the overall epidemiological data are still not coherent enough to allow any firm conclusions. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码:375 / 381
页数:7
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