Changes in Renal Peritubular Capillaries in Canine and Feline Chronic Kidney Disease

被引：5

作者：

Nakamura, R. ^{[1
]}

Yabuki, A. ^{[1
]}

Ichii, O. ^{[2
]}

Mizukawa, H. ^{[3
]}

Yokoyama, N. ^{[4
]}

Yamato, O. ^{[1
]}

机构：

[1] Kagoshima Univ, Joint Fac Vet Med, Lab Vet Clin Pathol, Kagoshima, Japan

[2] Hokkaido Univ, Fac Vet Med, Dept Basic Vet Sci, Lab Anat, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ, Fac Vet Med, Div Environm Vet Sci, Sapporo, Hokkaido, Japan

[4] Hokkaido Univ, Fac Vet Med, Lab Vet Internal Med, Dept Clin Sci, Sapporo, Hokkaido, Japan

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2018年 / 160卷

基金：

日本学术振兴会;

关键词：

capillary rarefaction; cat; chronic kidney disease; dog; ANGIOTENSIN-CONVERTING ENZYME; ENDOTHELIAL GROWTH-FACTOR; TUBULOINTERSTITIAL INJURY; CHRONIC HYPOXIA; FIBROSIS; ANGIOGENESIS; RAREFACTION; CARBOXYPEPTIDASE; DYSFUNCTION; MECHANISMS;

D O I：

10.1016/j.jcpa.2018.03.004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Renal capillary rarefaction is a crucial event that leads to tubulointerstitial damage during the progression of chronic kidney disease (CKD). In the present study, changes in CD34-positive renal capillaries were investigated in dogs and cats with CKD. A significant decrease in CD34-positive capillaries was observed in canine diseased kidneys, even at the early stage of disease. In cats, CD34-positive capillaries were well preserved in the diseased kidneys, with no link to the severity of CKD. Renal capillary rarefaction might be a trigger event that leads to the progression of CKD in dogs, rather than in cats. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：79 / 83

页数：5

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