A 948-bp sequence of the UL2 gene was amplified from the pseudorabies virus (PRV) Becker strain genome using polymerase chain reaction, and the gene identity was confirmed through further cloning and sequencing. Bioinformatic analysis indicated that the PRV UL2 gene encodes a putative polypeptide with 315-amino acid residues. Its encoding protein, designated UL2, has a conserved uracil-DNA glycosylase (UDG)_F1 domain, which is closely related to the herpesvirus UDG family and is highly conserved among its counterparts encoded by UDG genes. Multiple nucleic acid and amino acid sequence alignments suggested that the product of PRV UL2 has a relatively higher homology with UL2-like proteins of Alphaherpesvirinae than that of other subfamilies of Herpesviridae. In addition, phylogenetic analysis showed that PRV UL2 had a close evolutionary relationship with members of Alphaherpesvirinae, especially members of the genus Varicellovirus of bovine herpesvirus 1 and bovine herpesvirus 5. Antigen prediction indicated the presence of several potential B-cell epitopes in PRV UL2. In addition, secondary structure and 3-dimensional structure prediction revealed that PRV UL2 consisted predominantly of an alpha-helix. Taken together, these results provide molecular biological insight for the further study of the function and mechanism of UL2 during PRV infection.
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Sichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Wu, Ying
Cheng, Anchun
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Sichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Yaan, Peoples R China
Sichuan Agr Univ, Epizoot Dis Inst, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Cheng, Anchun
Wang, Mingshu
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Sichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Wang, Mingshu
Zhu, Dekang
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Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Zhu, Dekang
Jia, Renyong
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Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Jia, Renyong
Cui, Hengmin
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Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Cui, Hengmin
Luo, Qihui
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Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Luo, Qihui
Wang, Yi
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Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Wang, Yi
Xu, Zhiwen
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Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Xu, Zhiwen
Chen, Zhengli
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Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Chen, Zhengli
Chen, Xiaoyue
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Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Yaan, Peoples R China
Sichuan Agr Univ, Epizoot Dis Inst, Yaan, Peoples R ChinaSichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Yaan, Peoples R China
Chen, Xiaoyue
2010 4TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING (ICBBE 2010),
2010,