Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association?

被引：30

作者：

Buckner, JH

Nepom, GT

机构：

[1] Virginia Mason Res Ctr, Benaroya Res Inst, Seattle, WA 98101 USA

[2] Univ Washington, Sch Med, Seattle, WA USA

来源：

CURRENT OPINION IN RHEUMATOLOGY | 2002年 / 14卷 / 03期

关键词：

D O I：

10.1097/00002281-200205000-00011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human leukocyte antigen genes associated with rheumatoid arthritis are commonly found in the unaffected population, implying that causal mechanisms of disease involve interactions between these genes and other factors. A variety of approaches-genetic, structural, and immunologic-are used to explore possible molecular interactions that may contribute to understanding the basis for this disease association. The specific relation between human leukocyte antigen-DR4 alleles and rheumatoid arthritis remains one of the strongest and most thoroughly studied examples of human leukocyte antigen risk genes among human autoimmune disorders. (C) 2002 Lippincott Williams Wilkins, Inc.

引用

页码：254 / 259

页数：6

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