Recent advances in the synthesis of α-amino ketones

被引：62
作者：
Allen, Lewis A. T. [1 ]
Raclea, Robert-Cristian [2 ]
Natho, Philipp [1 ]
Parsons, Philip J. [1 ]
机构：
[1] Imperial Coll London, Dept Chem, Mol Sci Res Hub, London W12 0BZ, England
[2] MIT, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 03期
基金：
英国工程与自然科学研究理事会;
关键词：
CATALYZED ASYMMETRIC HYDROGENATION; ONE-POT SYNTHESIS; N-BROMOSUCCINIMIDE; OXIDATIVE AMINATION; EFFICIENT SYNTHESIS; BENZYLIC ALCOHOLS; TERMINAL ALKYNES; ENOL ETHERS; REARRANGEMENT; ROUTE;
D O I：
10.1039/d0ob02098b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Due to the importance of the amino ketone motif in synthetic and medicinal chemistry, the number of protocols developed in recent years has considerably increased. This review serves to collate and critically evaluate novel methodologies published since 2011 towards this high value synthon. The chapters are divided by the requisite functionality in the starting material, and an emphasis is placed on discussing functional group compatibility and resultant product substitution patterns. Throughout, applications to medicinal targets are highlighted and mechanistic details are presented, and we further provide a short outlook for future development and emerging potential within this area.
引用
收藏
页码：498 / 513
页数：16
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