Current events in immunotherapy for upper aerodigestive tract cancer

被引:8
|
作者
Outh-Gauer, Sophie [1 ]
Le Tourneau, Christophe [2 ,3 ]
Broudin, Chloe [1 ]
Scotte, Florian [4 ]
Roussel, Helene [1 ,5 ]
Hans, Stephane [6 ]
Mandavit, Marion [5 ]
Tartour, Eric [5 ,7 ]
Badoual, Cecile [1 ,5 ]
机构
[1] Hop Europeen Georges Pompidou, AP HP, Serv Anat Pathol, 20 Rue Leblanc, F-75015 Paris, France
[2] Inst Curie, Dept Med Oncol, F-75005 Paris, France
[3] Unite Inserm U900, F-75005 Paris, France
[4] Hop Europeen Georges Pompidou, AP HP, Unite Fonct Soins Oncol Support, Pole Cancerol Specialites, 20 Rue Leblanc, F-75015 Paris, France
[5] PARCC, Fac Paris Descartes, Inserm 970, Equipe 10, F-75015 Paris, France
[6] Hop Europeen Georges Pompidou, AP HP, Serv ORL & Chirurg Cerv Faciale, 20 Rue Leblanc, F-75015 Paris, France
[7] Hop Europeen Georges Pompidou, AP HP, Serv Immunol Biol, 20 Rue Leblanc, F-75015 Paris, France
关键词
PD-L1; PD-1; Head and neck; cancer; Immunotherapy; HPV; SQUAMOUS-CELL CARCINOMA; TUMOR-INFILTRATING LYMPHOCYTES; ANALOG SECRETORY CARCINOMA; CHIMERIC ANTIGEN RECEPTOR; DEATH LIGAND-1 EXPRESSION; HPV-ASSOCIATED HEAD; REGULATORY T-CELLS; PD-L1; EXPRESSION; NECK-CANCER; IFN-GAMMA;
D O I
10.1016/j.annpat.2016.12.013
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Head and neck (HN) carcinomas (mostly represented by squamous cell carcinomas [SCC]) still have a poor prognosis, which could be dramatically improved with immunotherapy. Tumor's microenvironment changes, caused by many endogenous or exogenous events, can correlate with prognosis and therapeutic response. Here, we review recent data regarding HNSCC, nasopharyngeal carcinomas (NPC) and salivary gland malignant tumors, all three being potential target of immunotherapies. About half of HNSCC exhibit PD-L1 expression, this expression being upregulated in HPV-positive tumors. In recent clinical trials, a better therapeutic response to anti-PD-1 has been obtained in patients with higher PD-L1 expression. Food and Drug Administration (FDA) approved the use of these therapeutics without the screening of patients regarding PD-L1 status. Activation status, density and localisation of TIL as well as PD-L2, gamma-interferon, inflammatory cytokines, epithelial-mesenchymal transition phenotype and mutational burden may all be potential therapeutic response markers. In Epstein-Barr Virus (EBV)-induced nasopharyngeal non-keratinizing cancer, PD-L1 is over-expressed compared to EBV negative-tumors. A 22 % response rate has been observed under anti-PD-1 treatment, among PD-L1-positive HNSCC patients. There is little data regarding microenvironment of salivary gland cancer. PD-L1 shows great heterogeneity in localisation, when expressed. A 11 % response rate has been obtained under anti-PD-1 treatment among PD-L1-positive NPC patients. A better understanding of immune checkpoint regulation processes needs to be achieved to allow patients with HN carcinomas to benefit from these promising immunotherapies. (C) 2016 Elsevier Masson SAS.
引用
收藏
页码:79 / 89
页数:11
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