Subcellular Localization of Thiol-Capped CdTe Quantum Dots in Living Cells

被引：28

作者：

Zhang, Yu ^{[1
]}

Mi, Lan ^{[1
]}

Xiong, Rongling ^{[1
]}

Wang, Pei-Nan ^{[1
]}

Chen, Ji-Yao ^{[2
,3
]}

Yang, Wuli ^{[4
,5
]}

Wang, Changchun ^{[4
,5
]}

Peng, Qian ^{[6
]}

机构：

[1] Fudan Univ, Dept Opt Sci & Engn, Key Lab Adv Photon Mat & Devices, Shanghai 200433, Peoples R China

[2] Fudan Univ, Surface Phys Lab, Natl Key Lab, Shanghai 200433, Peoples R China

[3] Fudan Univ, Dept Phys, Shanghai 200433, Peoples R China

[4] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China

[5] Fudan Univ, Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

[6] Univ Oslo, Dept Pathol, Natl Hosp Norwegian Radium Hosp, Oslo, Norway

来源：

NANOSCALE RESEARCH LETTERS | 2009年 / 4卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Cells; Confocal microscopy; Imaging; Quantum dots; Subcellular localization; LIVE CELLS; NANOCRYSTALS; ENDOCYTOSIS; TRACKING; TRANSPORT; DELIVERY;

D O I：

10.1007/s11671-009-9307-9

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Internalization and dynamic subcellular distribution of thiol-capped CdTe quantum dots (QDs) in living cells were studied by means of laser scanning confocal microscopy. These unfunctionalized QDs were well internalized into human hepatocellular carcinoma and rat basophilic leukemia cells in vitro. Co-localizations of QDs with lysosomes and Golgi complexes were observed, indicating that in addition to the well-known endosome-lysosome endocytosis pathway, the Golgi complex is also a main destination of the endocytosed QDs. The movement of the endocytosed QDs toward the Golgi complex in the perinuclear region of the cell was demonstrated.

引用

页码：606 / 612

页数：7