An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397

被引:15
作者
Fu, Fan [1 ]
Loh, Teck-Peng [1 ]
机构
[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
关键词
BORON ALDOL REACTIONS; DIELS-ALDER REACTION; CHIRAL SYNTHESIS; HOMOALLYLIC ALCOHOLS; ORGANIC-SYNTHESIS; 1,5-ASYMMETRIC INDUCTION; DIRECTED REDUCTION; METHYL KETONES; ALDEHYDES; ORGANOBORANES;
D O I
10.1016/j.tetlet.2009.03.019
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A highly convergent and asymmetric synthesis of the C11-C31 polyol fragment of RK-397 as a single isomer is accomplished via a catalytic enantioselective hetero-Diels-Alder reaction and an intermolecular olefin cross-metathesis as key steps. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3530 / 3533
页数:4
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