An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397

被引：15

作者：

Fu, Fan ^{[1
]}

Loh, Teck-Peng ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 26期

关键词：

BORON ALDOL REACTIONS; DIELS-ALDER REACTION; CHIRAL SYNTHESIS; HOMOALLYLIC ALCOHOLS; ORGANIC-SYNTHESIS; 1,5-ASYMMETRIC INDUCTION; DIRECTED REDUCTION; METHYL KETONES; ALDEHYDES; ORGANOBORANES;

D O I：

10.1016/j.tetlet.2009.03.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly convergent and asymmetric synthesis of the C11-C31 polyol fragment of RK-397 as a single isomer is accomplished via a catalytic enantioselective hetero-Diels-Alder reaction and an intermolecular olefin cross-metathesis as key steps. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3530 / 3533

页数：4

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