Novel Screening Paradigms for the Identification of Allosteric Modulators and/or Biased Ligands for Challenging G-Protein-Coupled Receptors

被引：3

作者：

Schann, Stephan ^{[1
]}

Neuville, Pascal ^{[1
,2
]}

Bouvier, Michel ^{[3
]}

机构：

[1] Domain Therapeut SA, Strasbourg, France

[2] Domain Therapeut NA Inc, Neomed Inst, Montreal, PQ, Canada

[3] Univ Montreal, Dept Biochem, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada

来源：

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 49 | 2014年 / 49卷

关键词：

GLUCAGON-LIKE PEPTIDE-1; FUNCTIONAL SELECTIVITY; ACTIVATION; DISCOVERY; OPPORTUNITIES; MECHANISMS; NANOBODIES; AGONIST; BINDING; TRV130;

D O I：

10.1016/B978-0-12-800167-7.00018-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：285 / 300

页数：16

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