10-Undecanhydroxamic acid, a hydroxamate derivative of the undecanoic acid, has strong antimicrobial activity through a mechanism that limits iron availability

被引：12

作者：

Ammendola, Serena ^{[1
]}

Lembo, Angelo ^{[2
]}

Battistoni, Andrea ^{[1
,3
]}

Tagliatesta, Pietro ^{[2
]}

Ghisalberti, Carlo ^{[4
]}

Desideri, Alessandro ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dipartimento Biol, I-00133 Rome, Italy

[2] Univ Roma Tor Vergata, Dipartimento Sci & Tecnol Chim, I-00133 Rome, Italy

[3] Consorzio Interuniv Inst Nazl Biostrutture & Bios, Rome, Italy

[4] Radjuva Res, Milan, Italy

来源：

FEMS MICROBIOLOGY LETTERS | 2009年 / 294卷 / 01期

关键词：

antimicrobial; hydroxamate; undecanoic acid; iron homeostasis; Fur; SALMONELLA-ENTERICA; PATHOGENIC BACTERIA; CHROMOSOMAL GENES; FATTY-ACIDS; SYSTEM; TYPHIMURIUM; VIRULENCE; AGENTS;

D O I：

10.1111/j.1574-6968.2009.01537.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Undecanoic acid (UDA) is a fatty acid with significant antimycotic activity. In this work we have synthesized 10-undecanhydroxamic acid, a hydroxamate derivative of the UDA, and tested its antimicrobial activity on different microorganisms. Our results demonstrate that this compound has higher efficacy than UDA against a variety of fungi and bacteria. Analysis of the intracellular concentration of protein involved in iron transport in Salmonella enterica serovar Typhimurium suggests that its antimicrobial effect actually relies on the ability to chelate iron ions, providing an efficient mechanism to interfere with microbial growth.

引用

页码：61 / 67

页数：7

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