Novel Insights on the Role of the Human Sperm Proteome

被引：0
作者：
Cannarella, Rossella [1 ]
Condorelli, Rosita A. [1 ]
Calogero, Aldo E. [1 ]
La Vignera, Sandro [1 ]
机构：
[1] Univ Catania, Dept Clin & Expt Med, Catania, Italy
来源：
PROTEIN AND PEPTIDE LETTERS | 2020年 / 27卷 / 12期
关键词：
Sperm proteome; fertilization; embryo development; epigenetic; gene ontology; male infertility; MASS-SPECTROMETRY; ACROSOME REACTION; PROTEINS; FERTILIZATION; BIOGENESIS; FRAGMENTS;
D O I：
10.2174/0919866527666200505115921
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The spermatozoon has classically been seen only as a paternal DNA transporter into the oocyte, thus underestimating the entire contribution of the male gamete to the embryo development. The advancement of the research supports that not only the sperm genome, but the entire sperm transcriptome and proteome carry crucial information for fertilization and embryo development. Altogether, 6871 proteins have been reported in spermatozoa so far. Their functional analysis has recently addressed to the sperm proteome a role in fertilization, preimplantation embryo development and paternal epigenetic inheritance. Targeted analysis of human spermatozoa is warranted to compile an evidence-based list of sperm-carried molecular targets in infertile patients.
引用
收藏
页码：1181 / 1185
页数：5
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