The gut microbiota and its potential role in obesity

被引：28
作者：
Shabana [1 ]
Shahid, Saleem U. [1 ]
Irfan, Uzma [2 ]
机构：
[1] Univ Punjab, Dept Microbiol & Mol Genet, Lahore 54590, Pakistan
[2] Women Univ Multan, Multan 66000, Pakistan
来源：
FUTURE MICROBIOLOGY | 2018年 / 13卷 / 05期
关键词：
Archaea; microbiota; obesity; rodent; MOLECULAR BIOLOGICAL METHODS; HIGH-FAT DIET; WEIGHT-GAIN; BIFIDOBACTERIUM-ANIMALIS; INTESTINAL MICROBIOTA; LACTOBACILLUS-REUTERI; DIVERSITY; HEALTH; TRANSPLANTATION; INFLAMMATION;
D O I：
10.2217/fmb-2017-0179
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The human GI tract harbors a diverse and dynamic microbial community comprising bacteria, archaea, viruses and eukaryotic microbes, which varies in composition from individual to individual. A healthy microbiota metabolizes various indigestible dietary components of the host, maintains host immune home-ostasis and nutrient intake, but, an imbalanced microbiota has been reported to be associated with many diseases, including obesity. Rodent studies have produced evidence in support of the causal role of the gut microbiota in the development of obesity, however, such causal relationship is lacking in humans. The objective of this review is to critically analyze the vast information available on the composition, function and alterations of the gut microbiota in obesity and explore the future prospects of this research area.
引用
收藏
页码：589 / 603
页数：15
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