Cannabinoid Receptor Type 2 Activation in Atherosclerosis and Acute Cardiovascular Diseases

被引:23
作者
Carbone, Federico [1 ,2 ]
Mach, Francois [1 ]
Vuilleumier, Nicolas [3 ]
Montecucco, Fabrizio [2 ,3 ]
机构
[1] Univ Geneva, Fdn Med Res, Div Cardiol, Dept Med Specialties, CH-1211 Geneva, Switzerland
[2] Univ Genoa, IST Ist Nazl Ric Cancro, IRCCS Azienda Osped Univ San Martino, IST Ist Nazl Ric Cancro,Sch Med, I-16132 Genoa, Italy
[3] Univ Hosp Geneva, Dept Genet & Lab Med, Div Lab Med, CH-1211 Geneva, Switzerland
基金
瑞士国家科学基金会;
关键词
Atherosclerosis; cannabinoids; CB2; ischemia/reperfusion injury; ischemic stroke; CB2; RECEPTOR; NUCLEAR-FACTOR; ENDOCANNABINOID SYSTEM; ISCHEMIA-REPERFUSION; INFARCT SIZE; IN-VIVO; DIFFERENTIAL EXPRESSION; SIGNALING PATHWAYS; THERAPEUTIC TARGET; IMMUNE MODULATION;
D O I
10.2174/0929867321666140915141332
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the last decades, the cannabinoid system (comprising synthetic and endogenous cannabinoid agonists and antagonists, their receptors and degrading enzymes) has been shown to induce potent immunomodulatory activities in atherogenesis and acute ischemic complications. Different from the other cannabinoid receptors in which controversial results are reported, the selective activation of the cannabinoid receptor type 2 (CB2) has been shown to play anti-inflammatory and protective actions within atherosclerotic vessels and downstream ischemic peripheral organs. CB2 is a transmembrane receptor that triggers protective intracellular pathways in cardiac, immune and vascular cells in both human and animal models of atherosclerosis. Considering basic research data, medications activating CB2 function in the circulation or peripheral target organs might be a promising approach against atherogenesis. This review updates evidence from preclinical studies on different CB2-triggered pathways in atherosclerosis and acute ischemic events.
引用
收藏
页码:4046 / 4058
页数:13
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