The proinflammatory effects of chronic excessive exercise

被引：65
作者：
da Rocha, Alisson L. [1 ]
Pinto, Ana P. [1 ]
Kohama, Eike B. [1 ]
Pauli, Jose R. [2 ]
de Moura, Leandro P. [2 ]
Cintra, Dennys E. [3 ,4 ]
Ropelle, Eduardo R. [2 ]
da Silva, Adelino S. R. [1 ,5 ]
机构：
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto, SP, Brazil
[2] Univ Estadual Campinas, UNICAMP, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, Limeira, SP, Brazil
[3] Univ Estadual Campinas, UNICAMP, Sch Appl Sci, Lab Nutr Genom, Limeira, SP, Brazil
[4] Univ Estadual Campinas, UNICAMP, Sch Appl Sci, Nutrigen & Lipids Ctr, Limeira, SP, Brazil
[5] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, SP, Brazil
来源：
CYTOKINE | 2019年 / 119卷
基金：
巴西圣保罗研究基金会; 瑞典研究理事会;
关键词：
Overtraining; Inflammation; Insulin signaling pathway; Endoplasmic reticulum stress; Hepatic fat accumulation; Pathological cardiac hypertrophy; ENDOPLASMIC-RETICULUM STRESS; INFLAMMATORY CYTOKINES; OVERTRAINING SYNDROME; FOOD-INTAKE; LEADS; ACTIVATION; EXPRESSION; HYPOTHALAMUS; HYPERTROPHY; ADAPTATION;
D O I：
10.1016/j.cyto.2019.02.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chronic moderate-intensity exercise is an efficient non-pharmacological strategy to prevent and treat several diseases such as type 2 diabetes mellitus, cardiovascular and chronic obstructive pulmonary diseases, cancers, and Parkinson's disease. On the other hand, improving an athlete's performance requires completing high-intensity and volume exercise sessions. When the delicate balance between high-load exercise sessions and adequate recovery periods is disrupted, excessive training (known as overtraining) can lead to performance decline. The cytokine hypothesis considers that an imbalance involving excessive exercise and inadequate recovery induces musculoskeletal trauma, increasing the production and release of proinflammatory cytokines, mainly interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin 1 beta (IL-1beta), which interact with different organic systems, initiating most of the signs and symptoms linked to performance decrement. This leading article used recent data to discuss the scientific basis of Smith's cytokine theory and highlighted that the adverse effects of excessive exercise go beyond performance decline, proposing a multi-organ approach for this issue. These recent insights will allow coaches and exercise physiologists to develop strategies to avoid chronic excessive exercise-induced adverse outcomes.
引用
收藏
页码：57 / 61
页数：5
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