Effects of Malnutrition on Children's Immunity to Bacterial Antigens in Northern Senegal

被引：11

作者：

Gaayeb, Lobna ^{[1
,2
]}

Sarr, Jean B. ^{[2
]}

Cames, Cecile ^{[3
]}

Pincon, Claire ^{[4
]}

Hanon, Jean-Baptiste ^{[1
]}

Ndiath, Mamadou O. ^{[5
]}

Seck, Modou ^{[2
]}

Herbert, Fabien ^{[1
]}

Sagna, Andre B. ^{[2
]}

Schacht, Anne-Marie ^{[1
]}

Remoue, Franck ^{[6
]}

Riveau, Gilles ^{[1
,2
]}

Hermann, Emmanuel ^{[1
]}

机构：

[1] Univ Lille Nord France, CNRS, INSERM, U1019,UMR8204,Inst Pasteur Lille,CIIL, Lille, France

[2] Ctr Rech Biomed Espoir Sante EPLS, St Louis, Senegal

[3] Ctr Hosp Univ Fann, Inst Rech Dev, Ctr Reg Rech & Format Prise Charge Clin, UMI Trans6Hmi 233, Dakar, Senegal

[4] Univ Lille Nord France, Fac Pharm, Dept Biostat, Lille, France

[5] UCAD, Inst Rech Dev Hann, Inst Rech Dev, UMR 198,URMITE, Dakar, Senegal

[6] Univ Montpellier 1 & 2, Inst Rech Dev 224, Inst Rech Dev, UMR MIVEGEC,CNRS5290,CREC, Cotonou, Benin

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2014年 / 90卷 / 03期

关键词：

ENVIRONMENTAL DETERMINANTS; POSTNATAL ENVIRONMENTS; ANTIBODY-RESPONSES; BIRTH-WEIGHT; EARLY-LIFE; VACCINATION; TETANUS; GAMBIA; INFECTION; INFANTS;

D O I：

10.4269/ajtmh.12-0657

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To evaluate immunity to vaccine-preventable diseases according to nutritional status, a longitudinal study was conducted in Senegalese children ages 1-9 years old. A linear regression analysis predicted that weight for age was positively associated with immunoglobulin G (IgG) response to tetanus toxoid in children born during the rainy season or at the beginning of the dry season. A relationship between village, time of visits, and levels of antibodies to tetanus showed that environmental factors played a role in modulating humoral immunity to tetanus vaccine over time. Moreover, a whole-blood stimulation assay highlighted that the production of interferon-gamma (IFN-gamma) in response to tetanus toxoid was compromised in stunted children. However, the absence of cytokine modulation in response to Mycobacterium tuberculosis-purified protein derivatives and phytohemagglutinin suggests that the overall ability to produce IFN-gamma was preserved in stunted children. Therefore, these results show that nutritional status can specifically alter the efficacy of long-lasting immunity to tetanus.

引用

页码：566 / 573

页数：8

共 33 条

[31] Mothers prolong breastfeeding of undernourished children in rural Senegal [J].