Silent chromatin at the middle and ends: lessons from yeasts

被引：58
作者：
Buehler, Marc [1 ]
Gasser, Susan M. [1 ]
机构：
[1] Friedrich Miescher Inst Biomed Res, Epigenet Focal Area, CH-4058 Basel, Switzerland
来源：
EMBO JOURNAL | 2009年 / 28卷 / 15期
关键词：
heterochromatin; RNA; silencing; RNA-POLYMERASE-II; SACCHAROMYCES-CEREVISIAE TELOMERES; POSITION-EFFECT VARIEGATION; H3; LYSINE-9; METHYLATION; REPEAT-CONTAINING RNA; DOMAIN PROTEIN MPS3; ACETYL-ADP-RIBOSE; FISSION YEAST; HISTONE H3; SCHIZOSACCHAROMYCES-POMBE;
D O I：
10.1038/emboj.2009.185
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic centromeres and telomeres are specialized chromosomal regions that share one common characteristic: their underlying DNA sequences are assembled into heritably repressed chromatin. Silent chromatin in budding and fission yeast is composed of fundamentally divergent proteins that assemble very different chromatin structures. However, the ultimate behaviour of silent chromatin and the pathways that assemble it seem strikingly similar among Saccharomyces cerevisiae (S. cerevisiae), Schizosaccharomyces pombe (S. pombe) and other eukaryotes. Thus, studies in both yeasts have been instrumental in dissecting the mechanisms that establish and maintain silent chromatin in eukaryotes, contributing substantially to our understanding of epigenetic processes. In this review, we discuss current models for the generation of heterochromatic domains at centromeres and telomeres in the two yeast species. The EMBO Journal (2009) 28, 2149-2161. doi:10.1038/emboj.2009.185; Published online 23 July 2009
引用
收藏
页码：2149 / 2161
页数：13
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