Defective expression and modulation of B7-2/CD86 on B cells in B cell chronic lymphocytic leukemia

被引：9

作者：

Dai, Zhen-sheng ^{[1
]}

Chen, Qin-fen ^{[2
]}

Lu, Hong-zhou ^{[1
]}

Xie, Yi ^{[2
]}

机构：

[1] Fudan Univ, Shanghai Publ Hlth Clin Ctr Affiliated, Dept Infect Dis, Shanghai 201508, Peoples R China

[2] Fudan Univ, Dept Hematol, Affiliated Huashan Hosp, Shanghai 200040, Peoples R China

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2009年 / 89卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Leukemia; B cell; Chronic; Costimulatory; B7; Expression; Interferon-gamma;

D O I：

10.1007/s12185-009-0320-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Malignant monoclonal B cells of chronic B cell lymphocytic leukemia (B-CLL) usually fail to be cleared, which indicates important costimulatory molecules may be lacking. Among those costimulatory signals, B7-1/CD80 and B7-2/CD86 caused utmost attention. In this study, B7-1 and B7-2 expression on B cells in chronic B cell lymphocytic leukemia patients were detected. Data showed that B7-2 expression in chronic B cell lymphocytic leukemia patients is significantly lower than in normal people, which suggests defective B7-2 expression may be one of the pathogenic mechanisms of chronic B cell lymphocytic leukemia. Further, we confirmed interferon-gamma could induce B7-2 expression slightly and promote T-cell response against chronic B cell lymphocytic leukemia cells, indicating interferon-gamma has clinical value in chronic leukemia immunotherapy based on modulating B7-2 expression.

引用

页码：656 / 663

页数：8

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