Helicobacter pylori Virulence Factors-Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment

被引：225

作者：

Baj, Jacek ^{[1
]}

Forma, Alicja ^{[2
]}

Sitarz, Monika ^{[3
]}

Portincasa, Piero ^{[4
]}

Garruti, Gabriella ^{[5
]}

Krasowska, Danuta ^{[6
]}

Maciejewski, Ryszard ^{[1
]}

机构：

[1] Med Univ Lublin, Dept Anat, PL-20400 Lublin, Poland

[2] Med Univ Lublin, Chair & Dept Forens Med, PL-20090 Lublin, Poland

[3] Med Univ Lublin, Dept Conservat Dent Endodont, PL-20090 Lublin, Poland

[4] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Clin Med Augusto Murri, I-70124 Bari, Italy

[5] Univ Bari Aldo Moro, Med Sch, Dept Emergency & Organ Transplantat, Sect Endocrinol, Piazza G Cesare 11, I-70124 Bari, Italy

[6] Med Univ Lublin, Dept Dermatol Venerol & Paediat Dermatol, PL-20081 Lublin, Poland

来源：

CELLS | 2021年 / 10卷 / 01期

关键词：

Helicobacter pylori; virulence factor; pathogenicity; urease; cagA; vacA; BabA; SabA; OpiA; DupA; GAMMA-GLUTAMYL-TRANSPEPTIDASE; NEUTROPHIL-ACTIVATING PROTEIN; OUTER-MEMBRANE PROTEIN; HEAT-SHOCK-PROTEIN; LEWIS ANTIGEN-EXPRESSION; CHOLESTEROL ALPHA-GLUCOSYLTRANSFERASE; KATA-ASSOCIATED PROTEIN; T-CELL PROLIFERATION; INTACT DUPA CLUSTER; LONG-TYPE DUPA;

D O I：

10.3390/cells10010027

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gastric cancer constitutes one of the most prevalent malignancies in both sexes; it is currently the fourth major cause of cancer-related deaths worldwide. The pathogenesis of gastric cancer is associated with the interaction between genetic and environmental factors, among which infection by Helicobacter pylori (H. pylori) is of major importance. The invasion, survival, colonization, and stimulation of further inflammation within the gastric mucosa are possible due to several evasive mechanisms induced by the virulence factors that are expressed by the bacterium. The knowledge concerning the mechanisms of H. pylori pathogenicity is crucial to ameliorate eradication strategies preventing the possible induction of carcinogenesis. This review highlights the current state of knowledge and the most recent findings regarding H. pylori virulence factors and their relationship with gastric premalignant lesions and further carcinogenesis.

引用

页码：1 / 37

页数：37

共 383 条

[1] The Helicobacter pylori dupA: a novel biomarker for digestive diseases [J].