Role of nitric oxide and carbon monoxide in modulating the response of the rat hypothalamic-pituitary-adrenal axis to immune challenges

被引：0

作者：

Lee, S ^{[1
]}

Rivier, C ^{[1
]}

机构：

[1] Salk Inst, Clayton Fdn Labs Peptide Biol, La Jolla, CA 92037 USA

来源：

CONTROL MECHANISMS OF STRESS AND EMOTION: NEUROENDOCRINE-BASED STUDIES | 1999年 / 1185卷

关键词：

ACTH; gases; hypothalamus; rat; stress;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This chapter discusses our present knowledge of the influence exerted by nitric oxide (NO) and carbon monoxide (CO) in regulating the activity of the paraventricular nucleus (PVN) of the hypothalamus, as well as the release of ACTH and corticosterone. We show that in the intact rats, both gases stimulate PVN neuronal activity, and that blockade of their formation blunts the ACTH response to immune and non-immune stresses.

引用

页码：155 / 163

页数：9

共 24 条

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