Copper-Catalyzed Regioselective ortho C-H Cyanation of Vinylarenes

被引：114
|
作者：
Yang, Yang [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 33期
基金：
美国国家卫生研究院;
关键词：
C-H activation; copper; dearomatization; ligand design; synthetic methods; BONDS; DFT; CHLOROMETHYLNAPHTHALENE; MARKOVNIKOV; SELECTIVITY; ALKENES; OLEFINS; BINOL;
D O I：
10.1002/anie.201402449
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A copper-based catalytic technique for the regioselective ortho C-H cyanation of vinylarenes has been developed. This method provides an effective means for the selective functionalization of vinylarene derivatives. A copper-catalyzed cyanative dearomatization mechanism is proposed to account for the regiochemical course of this reaction.
引用
收藏
页码：8677 / 8681
页数：5
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