Measurement Nt-proBNP Circulating Concentrations in Heart Failure Patients with a New Point-Of-Care Assay

被引：9
作者：
Lepoutre, Thibault [1 ]
Rousseau, Michel F. [4 ]
Ahn, Sylvie A. [4 ]
Gruson, D. [1 ,2 ,3 ]
机构：
[1] Clin Univ St Luc, Dept Lab Med, B-1200 Brussels, Belgium
[2] Clin Univ St Luc, Inst Rech Expt & Clin, Pole Rech Endocrinol Diabet & Nutr, B-1200 Brussels, Belgium
[3] Catholic Univ Louvain, B-1200 Brussels, Belgium
[4] Clin Univ St Luc, Div Cardiol, B-1200 Brussels, Belgium
来源：
CLINICAL LABORATORY | 2013年 / 59卷 / 7-8期
关键词：
cardiac markers; natriuretic peptides; NYHA; severity; ACUTE CORONARY SYNDROMES; NATRIURETIC PEPTIDE; PERFORMANCE;
D O I：
10.7754/Clin.Lab.2012.120418
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: BNP (Brain Natriuretic Peptide) and Nt-proBNP (N-terminal-pro-Brain Natriuretic Peptide) are valuable markers for the diagnosis and prognosis of heart failure (HF). The AQT90 (R) FLEX is a newly released random access analyzer for point-of-care (POCT) measurement. The aim of our study was to determine Nt-proBNP concentrations in HF patients with the POCT assay. Methods: Nt-proBNP levels were measured in seventy seven HF patients and in thirty seven healthy volunteers. The results were compared with a central laboratory assay. Results: Nt-proBNP levels measured with the AQT90 (R) FLEX were significantly correlated with the comparison Nt-proBNP assay and were related to HF severity. Conclusions: Nt-proBNP testing with the AQT 90 (R) FLEX analyzer is comparable to the central lab assay and may offer the advantages of POCT testing for the diagnosis and prognosis of heart failure.
引用
收藏
页码：831 / 835
页数：5
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