Viral pathogens in acute exacerbations of chronic obstructive pulmonary disease

被引：52

作者：

Camargo, Carlos A., Jr. ^{[1
]}

Ginde, Adit A. ^{[2
,3
]}

Clark, Sunday ^{[4
]}

Cartwright, Charles P. ^{[5
]}

Falsey, Ann R. ^{[6
]}

Niewoehner, Dennis E. ^{[7
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Emergency Med,EMNet Coordinating Ctr, Boston, MA 02114 USA

[2] Univ Colorado, Dept Emergency Med, Aurora, CO USA

[3] Beth Israel Deaconess Med Ctr, Dept Emergency Med, Boston, MA 02215 USA

[4] Univ Pittsburgh, Div Gen Internal Med, Pittsburgh, PA USA

[5] Hennepin Cty Med Ctr, Dept Lab Med & Pathol, Minneapolis, MN 55415 USA

[6] Univ Rochester, Dept Med, Rochester, NY USA

[7] Vet Affairs Med Ctr, Pulm Sect, Minneapolis, MN USA

来源：

INTERNAL AND EMERGENCY MEDICINE | 2008年 / 3卷 / 04期

关键词：

COPD; Exacerbation; Virus; Infection; Pulmonary; Emergency department;

D O I：

10.1007/s11739-008-0197-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of this study is to determine the prevalence of respiratory syncytial virus (RSV) and other viral respiratory pathogens in emergency department (ED) patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). COPD patients presenting to the ED with < 10 days of AECOPD symptoms were eligible. We used PCR to test nasal swabs for common viral respiratory pathogens. We completed viral studies on 76 patients from two EDs. Patients had a mean age of 72 years, and were 68% male, 99% white, and 29% current smokers. Influenza vaccination was reported by 87%. Viruses were detected in 19 of 76 patients (25%). These included RSV A (2) and B (4); parainfluenza 1 (1), 2 (0), and 3 (2); influenza A (3) and B (0); rhinovirus ( 4); and human metapneumovirus (3). A putative viral etiology was identified in 25% of AECOPD presenting for emergency care, of which approximately one-third were RSV-related.

引用

页码：355 / 359

页数：5

共 27 条

[1] Improved detection of rhinoviruses in clinical samples by using a newly developed nested reverse transcription-PCR assay [J].