Natural regulatory T cells: mechanisms of suppression

被引：576

作者：

Miyara, Makoto ^{[1
]}

Sakaguchi, Shimon

机构：

[1] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto 6068507, Japan

[2] Japan Sci & Technol Agcy, CREST, Kawaguchi 3320012, Japan

来源：

TRENDS IN MOLECULAR MEDICINE | 2007年 / 13卷 / 03期

关键词：

IMMUNOLOGICAL SELF-TOLERANCE; TRANSCRIPTION FACTOR FOXP3; NF-KAPPA-B; CUTTING EDGE; IN-VIVO; AUTOIMMUNE-DISEASE; TGF-BETA; DENDRITIC CELLS; MEDIATED SUPPRESSION; INTERLEUKIN (IL)-2;

D O I：

10.1016/j.molmed.2007.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural FOXP3(+)TD25(+)CD(+) regulatory T cells (Tregs) actively suppress pathological and physiological immune responses, contributing to the maintenance of immunological self-tolerance and immune homeostasis. Various molecular and cellular events have been described to explain the mechanism(s) of Treg-mediated suppression. However, none of the proposed mechanisms can explain all aspects of suppression. It is probable that various combinations of several mechanisms are operating, depending on the milieu and the type of immune responses, although there might be a single key mechanism that has a predominant role. Further studies of suppression and search for Treg-specific cell surface molecules are required for potential clinical application to treat and prevent immunological diseases and to control immune responses for the benefit of the host.

引用

页码：108 / 116

页数：9

共 89 条

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