Studies with azoles and benzoazoles: A novel simple approach for synthesis of 3-functionally substituted 3-acylindoles

被引：41

作者：

Abdel-Motaleb, Ramadan Maawad

Makhloof, Abdel-Moneim Abdel-Salam

Ibrahim, Hamada Mohamed

Elnagdi, Mohamed Hilmy ^{[1
]}

机构：

[1] Fayoum Univ, Dept Chem, Fac Sci, Al Fayyum, Egypt

[2] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 01期

关键词：

D O I：

10.1002/jhet.5570440119

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Substituted acylindoles 8 are obtained via refluxing carboxylic acids with indole in acetic anhydride solutions. The formed 3-substituted acylindole 8a is readily converted into 4-aminopyrazol-3-ylindoles 20, and into 22. Indole reacts with chloroacetyl chloride to yield: 3-chloroacetylindole 9 which could also be utilized for synthesis of a number of 3-substituted indoles.

引用

页码：109 / 114

页数：6

共 12 条

[1]

Acheson RM, 1976, INTRO CHEM HETEROCYC

[2] SYNTHESIS AND REACTIONS OF SOME 3-(2-HALOACYL)INDOLES [J].