Preparation and Characterization of Novel Quaternized Cellulose Nanoparticles as Protein Carriers

被引：45

作者：

Song, Yongbo ^{[1
,2
]}

Zhou, Jinping ^{[1
,2
]}

Li, Qian ^{[1
,2
]}

Guo, Yi ^{[1
,2
]}

Zhang, Lina ^{[1
,2
]}

机构：

[1] Wuhan Univ, Minist Educ, Dept Chem, Wuhan 430072, Peoples R China

[2] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2009年 / 9卷 / 09期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

BSA; ionic crosslinking; nanoparticles; protein carriers; quaternized cellulose; structure; DRUG-DELIVERY SYSTEMS; CHITOSAN NANOPARTICLES; AQUEOUS DISPERSIONS; MACROMOLECULES; HYDROGELS; POLYSACCHARIDES; PARTICLES; ALGINATE; WATER;

D O I：

10.1002/mabi.200800371

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quaternized cellulose (QC) nanciparticles were prepared in distilled water by ionic crosslinking of QC with sodium tripolyphosphate (TPP) for the first time. BSA as a model protein drug was used to investigate the loading and release features of the nanciparticles. The results indicated that QC nanoparticles had high loading efficiency and capacity for BSA. The in vitro BSA release of the QC nanoparticles displayed a burst effect in the first 2 h and then a slow continuous release. Nanoparticles with a higher DS of QC showed a decrease in particle size, an increase in zeta potential, a higher loading efficiency and a slower drug-release profile. These studies demonstrated that QC nanoparticles are potential protein carriers, and that their physicochernical properties and release profile could be easily adjusted.

引用

页码：857 / 863

页数：7

共 33 条

[1] Effects of preparative parameters on the properties of chitosan hydrogel beads containing Candida rugosa lipase [J].