The effects of bupivacaine and neostigmine on articular cartilage and synovium in the rabbit knee joint

被引:72
作者
Dogan, N
Erdem, AF
Erman, Z
Kizilkaya, M
机构
[1] Ataturk Univ, Sch Med, Dept Anaesthesia, TR-25240 Erzurum, Turkey
[2] Ataturk Univ, Sch Med, Dept Pathol, TR-25240 Erzurum, Turkey
关键词
bupivacaine; neostigmine; anaesthetics; intra-articular analgesia; articular cartilage; synovial membrane; knee joint; histopathological changes;
D O I
10.1177/147323000403200509
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We investigated the effects of intra-articular injections of bupivacaine and neostigmine on articular cartilage and the synovial membrane of rabbit knee joints. Saline, bupivacaine or neostigmine were each administered intra-articularly into 15 knee joints. Five joints per drug treatment were prepared for histopathological examination 24 h, 48 h and 10 days after injection. A pathologist examined the histological samples for inflammation of the articular cartilage, inflammatory cell infiltration, hypertrophy and hyperplasia of the synovial membrane, in a blinded manner. There were no histopathological changes in the saline-treated control joints. joints treated with bupivacaine and neostigmine showed significantly more histopathological changes than control joints. joints treated with neostigmine showed significantly more histopathological changes than those treated with bupivacaine, except for articular cartilage inflammation on day 10. We conclude that intra-articular bupivacaine and neostigmine cause histopathological changes in rabbit knee joints, with neostigmine having a greater effect than bupivacaine.
引用
收藏
页码:513 / 519
页数:7
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