A convenient synthetic route to oligonucleotide conjugates

被引：19
|
作者：
Harrison, JG [1 ]
Balasubramanian, S [1 ]
机构：
[1] UNIV CAMBRIDGE,DEPT CHEM,CAMBRIDGE CB2 1EW,ENGLAND
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 08期
关键词：
ANTISENSE OLIGONUCLEOTIDES; ASSOCIATION; LIPOSOMES; AGENTS; DNA;
D O I：
10.1016/S0960-894X(97)00152-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of oligodeoxyribonucleotide 13mers conjugated to cholic, folic, Lipoic and pantothenic acids through thioether and disulphide bonds is described employing a convenient methodology which involves initial preparation of cysteinyl derivatives of the acids on solid phase. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：1041 / 1046
页数：6
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