Cupric Oxide Coating That Rapidly Reduces Infection by SARS-CoV-2 via Solids

被引:98
作者
Hosseini, Mohsen [1 ,2 ]
Chin, Alex W. H. [3 ]
Behzadinasab, Saeed [1 ,2 ]
Poon, Leo L. M. [3 ,4 ]
Ducker, William A. [1 ,2 ]
机构
[1] Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA
[2] Virginia Tech, Ctr Soft Matter & Biol Phys, Blacksburg, VA 24061 USA
[3] Univ Hong Kong, LKS Fac Med, Sch Publ Hlth, Hong Kong, Peoples R China
[4] Univ Hong Kong, LKS Fac Med, HKU Pasteur Res Pole, Hong Kong, Peoples R China
基金
美国国家科学基金会;
关键词
SARS-CoV-2; coronavirus; coating; CuO; cupric oxide; viricidal; COVID-19; TRANSMISSION ELECTRON-MICROSCOPY; RAY PHOTOELECTRON-SPECTROSCOPY; INFLUENZA-VIRUS; CUO; COPPER; NANOPARTICLES; CU2O; SIZE; REDUCTION; NANOWIRES;
D O I
10.1021/acsami.0c19465
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The ongoing COVID-19 pandemic has created a need for coatings that reduce infection from SARS-CoV-2 via surfaces. Such a coating could be used on common touch surfaces (e.g., door handles and railings) to reduce both disease transmission and fear of touching objects. Herein, we describe the design, fabrication, and testing of a cupric oxide anti-SARS-CoV-2 coating. Rapid loss of infectivity is an important design criterion, so a porous hydrophilic coating was created to allow rapid infiltration of aqueous solutions into the coating where diffusion distances to the cupric oxide surface are short and the surface area is large. The coating was deposited onto glass from a dispersion of cuprous oxide in ethanol and then thermally treated at 700 degrees C for 2 h to produce a CuO coating that is approximate to 30 mu m thick. The heat treatment oxidized the cuprous oxide to cupric oxide and sintered the particles into a robust film. The SARS-CoV-2 infectivity from the CuO film was reduced by 99.8% in 30 min and 99.9% in 1 h compared to that from glass. The coating remained hydrophilic for at least 5 months, and there was no significant change in the cross-hatch test of robustness after exposure to 70% ethanol or 3 wt % bleach.
引用
收藏
页码:5919 / 5928
页数:10
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