Myocardial and peripheral concentrations of β-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty

被引：9

作者：

Chang, MCK

Lee, AYS ^{[1
]}

Lin, WY

Chen, TJ

Shyu, MY

Chang, WF

机构：

[1] Jen Ai Hosp, Div Cardiol, Taichung, Taiwan

[2] Jen Ai Hosp, Div Nucl Med, Taichung, Taiwan

来源：

JAPANESE HEART JOURNAL | 2004年 / 45卷 / 03期

关键词：

endogenous opioid peptides; myocardial ischemia and reperfusion;

D O I：

10.1536/jhj.45.365

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is substantial evidence indicating that endogenous opioid peptides are involved in the pathophysiology of myocardial ischemia and reperfusion. We measured the myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty. The results indicate that in patients with coronary artery disease, there was an augmented myocardial concentration of beta-endorphin. Moreover, there was an increased peripheral concentration of beta-endorphin following myocardial ischemia and reperfusion. The data support the previous notion that endogenous opioid peptides are involved in the pathophysiology of ischemic heart disease.

引用

页码：365 / 371

页数：7

共 19 条

[11] THE ROLE OF ENDOGENOUS OPIOIDS IN CONGESTIVE-HEART-FAILURE - EFFECTS OF NALMEFENE ON SYSTEMIC AND REGIONAL HEMODYNAMICS IN DOGS [J].