Steroeselective synthesis of β-amino ketones via direct Mannich-type reactions, catalyzed with ZrOCl2•8H2O under solvent-free conditions

被引：98
作者：
Eftekhari-Sis, Bagher
Abdollahifar, Amir
Hashemi, Mohammed M.
Zirak, Maryam
机构：
[1] Sharif Univ Technol, Dept Chem, Tehran, Iran
[2] Tabriz Univ, Dept Organ Chem, Tabriz, Iran
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2006卷 / 22期
关键词：
direct Mannich-type reaction; beta-amino ketones; zirconium oxychloride; solvent-free conditions; SILYL ENOL ETHERS; ZIRCONIUM TETRACHLORIDE; HIGHLY EFFICIENT; ONE-POT; ASYMMETRIC REDUCTION; CARBONYL-COMPOUNDS; OXIDE PERCHLORATE; ORGANIC-SYNTHESIS; ALDEHYDES; CONDENSATION;
D O I：
10.1002/ejoc.200600493
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
At room temperature, zirconium oxychloride (ZrOCl2 center dot 8H(2)O) efficiently catalyzes the direct Mannich-type reaction of a variety of in situ generated aldimines using aldehydes and anilines with ketones in a three-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the corresponding beta-amino ketones in good to high yields with good to excellent stereoselectivities. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006.
引用
收藏
页码：5152 / 5157
页数：6
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