Improved Yields for the Palladium-Mediated 11C-Carbonylation Reaction Using Microwave Technology

被引：17

作者：

Dahl, Kenneth ^{[1
]}

Schou, Magnus ^{[2
]}

Rahman, Obaidur ^{[1
]}

Halldin, Christer ^{[1
]}

机构：

[1] Karolinska Hosp, Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, S-17176 Stockholm, Sweden

[2] Karolinska Hosp, Karolinska Inst, Dept Clin Neurosci, AstraZeneca Translat Sci Ctr,PET Ctr Excellence, S-17176 Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 02期

关键词：

Medicinal chemistry; Radiopharmaceuticals; Microwave chemistry; Radiochemistry; Isotopic labeling; Carbonylation; CARBOXYLIC-ACIDS; ARYL; MONOXIDE; CARBONYLATION; AMINES; HALIDES; AMIDES; PET;

D O I：

10.1002/ejoc.201300989

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave heating technology was applied for the palladium-mediated C-11-carbonylation of aryl halides and triflates at ambient pressure using xantphos as supporting ligand. Improved yields were observed for the C-11-aminocarbonylation of electron-deficient aryl halides in comparison to thermal heating and the approach even allowed the use of an aryl chloride as substrate. The scope of this reaction was further extended to C-11-labeled aryl acid and two C-11-labeled aryl esters.

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页码：307 / 310

页数：4

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