Field Guide to Challenges and Opportunities in Antibody Drug Conjugates for Chemists

被引：79

作者：

Gordon, Mallory R. ^{[1
]}

Canakci, Mine ^{[2
]}

Li, Longyu ^{[1
]}

Zhuang, Jiaming ^{[1
]}

Osborne, Barbara ^{[2
,3
]}

Thayumanavan, S. ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[2] Univ Massachusetts, Mol & Cellular Biol Program, Amherst, MA 01003 USA

[3] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA

来源：

BIOCONJUGATE CHEMISTRY | 2015年 / 26卷 / 11期

基金：

美国国家卫生研究院;

关键词：

ACUTE MYELOID-LEUKEMIA; SITE-SPECIFIC CONJUGATION; METASTATIC BREAST-CANCER; PICTET-SPENGLER LIGATION; MONOCLONAL-ANTIBODY; IN-VIVO; GEMTUZUMAB OZOGAMICIN; CALICHEAMICIN CONJUGATE; TRASTUZUMAB EMTANSINE; PROTEIN CONJUGATION;

D O I：

10.1021/acs.bioconjchem.5b00399

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Antibody-drug conjugates have attracted a great amount of attention as a therapeutic strategy for diseases where targeting specific tissues and cells are critical components, such as in cancer therapy. Although promising, the number of approved ADC drugs is relatively limited. This emanates from the challenges associated with generating the conjugates and the complexities associated with the stability requirements for these conjugates during circulation and after reaching the target. Here, we provide a comprehensive overview of the design challenges facing the ADC field. These challenges also provide several unique research and development opportunities, which are also highlighted throughout the review.

引用

页码：2198 / 2215

页数：18

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