Temporal Appearance of Plasmid-Mediated Quinolone Resistance Genes

被引：67
作者：
Jacoby, George A. [1 ]
Gacharna, Nancy [1 ]
Black, Todd A. [2 ]
Miller, George H. [3 ]
Hooper, David C. [4 ]
机构：
[1] Lahey Clin Fdn, Burlington, MA USA
[2] Schering Plough Res Inst, Kenilworth, NJ USA
[3] Blanca Pharmaceut, Menlo Pk, CA USA
[4] Massachusetts Gen Hosp, Boston, MA 02114 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 04期
基金：
美国国家卫生研究院;
关键词：
ESCHERICHIA-COLI; KLEBSIELLA-PNEUMONIAE; AMIKACIN RESISTANCE; DNA HYBRIDIZATION; AAC(6')-IB-CR; EMERGENCE; DETERMINANTS; PREVALENCE; STRAINS; ENZYME;
D O I：
10.1128/AAC.01447-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
One hundred fifty AAC(6')-Ib-positive gram-negative isolates collected between 1981 and 1991 were examined by PCR for the presence of the aac(6')-Ib-cr variant and other plasmid-mediated quinolone resistance (PMQR) genes. None had the aac(6')-Ib-cr variant, qnrA, qnrS, qnrC, or qepA, but two strains collected in 1988 had qnrB alleles, making these the earliest known PMQR genes.
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收藏
页码：1665 / 1666
页数：2
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