Identifying Candidate Genes for Type 2 Diabetes Mellitus and Obesity through Gene Expression Profiling in Multiple Tissues or Cells

被引：50

作者：

Chen, Junhui ^{[1
]}

Meng, Yuhuan ^{[1
,2
]}

Zhou, Jinghui ^{[1
]}

Zhuo, Min ^{[1
]}

Ling, Fei ^{[1
]}

Zhang, Yu ^{[3
]}

Du, Hongli ^{[1
]}

Wang, Xiaoning ^{[1
,2
]}

机构：

[1] S China Univ Technol, Guangdong Prov Key Lab Fermentat & Enzyme Engn, Sch Biosci & Bioengn, Guangzhou 510006, Guangdong, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Beijing 100853, Peoples R China

[3] Guangdong Lab Animals Monitoring Inst, Guangzhou 510555, Guangdong, Peoples R China

来源：

JOURNAL OF DIABETES RESEARCH | 2013年 / 2013卷

基金：

中国国家自然科学基金;

关键词：

PROTEIN-KINASE-C; GENOME-WIDE ASSOCIATION; GLUCOSE-HOMEOSTASIS; PHOSPHOLIPASE-C; ADIPOSE-TISSUE; INSULIN; LOCI; TRANSPORT; LINKS;

D O I：

10.1155/2013/970435

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 Diabetes Mellitus (T2DM) and obesity have become increasingly prevalent in recent years. Recent studies have focused on identifying causal variations or candidate genes for obesity and T2DM via analysis of expression quantitative trait loci (eQTL) within a single tissue. T2DM and obesity are affected by comprehensive sets of genes in multiple tissues. In the current study, gene expression levels in multiple human tissues from GEO datasets were analyzed, and 21 candidate genes displaying high percentages of differential expression were filtered out. Specifically, DENND1B, LYN, MRPL30, POC1B, PRKCB, RP4-655J12.3, HIBADH, and TMBIM4 were identified from the T2DM-control study, and BCAT1, BMP2K, CSRNP2, MYNN, NCKAP5L, SAP30BP, SLC35B4, SP1, BAP1, GRB14, HSP90AB1, ITGA5, and TOMM5 were identified from the obesity-control study. The majority of these genes are known to be involved in T2DM and obesity. Therefore, analysis of gene expression in various tissues using GEO datasets may be an effective and feasible method to determine novel or causal genes associated with T2DM and obesity.

引用

页数：9

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