The dynamic blood-brain barrier

被引:476
作者
Keaney, James [1 ]
Campbell, Matthew [1 ]
机构
[1] Trinity Coll Dublin, Smurfit Inst Genet, Dublin 2, Ireland
关键词
Alzheimer's disease; astrocytes; blood-brain barrier; GLUT-1; gut microbiota; Mfsd2a; neurovascular unit; pericytes; tight junctions; transcytosis; CENTRAL-NERVOUS-SYSTEM; ENDOTHELIAL ADHERENS JUNCTIONS; CEREBRAL GLUCOSE-METABOLISM; AMYLOID-BETA; TIGHT JUNCTIONS; ALZHEIMERS-DISEASE; CEREBROVASCULAR INTEGRITY; PERICYTE LOSS; CNS; CELLS;
D O I
10.1111/febs.13412
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
With the endothelium as its central unit, the blood-brain barrier (BBB) is a complex multicellular structure separating the central nervous system (CNS) from the systemic circulation. Disruption of the BBB has now been implicated in a multitude of acute and chronic CNS disorders indicating the potentially devastating effects of BBB breakdown on brain function. However, the healthy BBB is not an impermeable wall, but rather a communication centre', responding to and passing signals between the CNS and blood. New studies are identifying BBB-specific transport pathways that tightly regulate the entry and exit of molecules to and from the brain. They are revealing a highly plastic barrier in which dynamic changes in BBB components like paracellular tight junction complexes can contribute to BBB maintenance. Here, we provide a succinct overview of the current state-of-play in BBB research and summarize novel findings into BBB regulation in homeostatic regulation of the brain.
引用
收藏
页码:4067 / 4079
页数:13
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