Activity of glutathione-metabolizing and antioxidant enzymes in malignant and benign tumors of human lungs

被引：20
|
作者：
Korotkina, RN [1 ]
Matskevich, GN [1 ]
Devlikanova, AS [1 ]
Vishnevskii, AA [1 ]
Kunitsyn, AG [1 ]
Karelin, AA [1 ]
机构：
[1] Russian Acad Med Sci, Clin & Biochem Lab, Dept Thorac Surg, AV Vishnevskii Inst Surg, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 06期
关键词：
lung cancer; glutathione; glutathione-metabolizing enzymes; superoxide dismutase; catalase;
D O I：
10.1023/A:1020206514239
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We measured the content of glutathione and activity of glutathione-metabolizing and antioxidant enzymes superoxide dismutase and catalase in samples obtained from 52 patients with malignant lung tumors and 20 patients with benign lung tumors. The content of glutathione and activity of glutathione-metabolizing enzymes underwent similar changes, but these changes were most pronounced in malignant tumors. Antioxidant enzyme activity changed insignificantly in benign tumors, but significantly decreased in malignant tumors (squamous cell carcinoma and adenocarcinoma). The severity of changes in malignant tumors depended on the degree of malignancy. Most pronounced changes were observed in adenocarcinoma, which often metastasizes and is resistant to chemotherapy. These changes were least pronounced in bronchoalveolar carcinoma sensitive to chemotherapy.
引用
收藏
页码：606 / 608
页数：3
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