MT1-MMP: an enzyme with multidimensional regulation

被引：68

作者：

Itoh, Y

Seiki, M ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Div Canc Cell Res, Minato Ku, Tokyo 1088639, Japan

[2] Univ London Imperial Coll Sci Technol & Med, Kennedy Inst, Div Rheumatol, Dept Matrix Biol, London W6 8LH, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 06期

关键词：

D O I：

10.1016/j.tibs.2004.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity of membrane-type 1 matrix metalloproteinase (MT1-MMP) is a double-edged sword - it is crucial for both physiological processes and disease progression. MT1-MMP modifies various cellular functions and it is, sthus, regulated precisely as a proteinase and as a membrane protein. Recent studies have further revealed that the function of MT1-MMP is modified and regulated by O-glycosylation, interaction with CD44, internalization and recycling. Such multidimensional mechanisms enable MT1-MMP to be regulated spatially and temporally, and are essential for its proper functioning on the cell surface.

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收藏

页码：285 / 289

页数：5

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