Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection

被引：102

作者：

Lankester, AC

Heemskerk, B

Claas, ECJ

Schilham, MW

Beersma, MFC

Bredius, RGM

van Tol, MJD

Kroes, ACM

机构：

[1] Leiden Univ, Med Ctr, Dept Pediat, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Med Microbiol, NL-2300 RC Leiden, Netherlands

来源：

CLINICAL INFECTIOUS DISEASES | 2004年 / 38卷 / 11期

关键词：

D O I：

10.1086/420817

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adenovirus (AdV) infections are an increasingly frequent and potentially fatal complication in allogeneic stem cell transplant recipients. To determine the antiviral potential of ribavirin in an unbiased way, 4 patients without immune recovery were prospectively analyzed by quantitative measurement of plasma AdV DNA load. Administration of ribavirin at the first signs of AdV dissemination was not accompanied by a decrease in the plasma AdV DNA load in any of these patients, and an increase in the AdV load was even documented in 3. These observations question the potential of ribavirin to improve the outcome for patients with disseminating AdV infection and support a critical evaluation of antiviral treatments for AdV infection that involves the kinetics of virus DNA load as an objective parameter of viral replication.

引用

收藏

页码：1521 / 1525

页数：5

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