DECAES - DEcomposition and Component Analysis of Exponential Signals

Combinations of multiple exponentially decaying signals are found across many disciplines of science. Decomposition of these multi-exponential signals into their individual components provides insight into the various contributors to the signal. Magnetic resonance images, for instance, can be acquired with multiple gradient or spin echoes to provide voxel by voxel multi-exponential T2* or T2 decays, respectively. With their millions of voxels, these images make the task of decomposition into individual exponentials computationally challenging. Current implementations take several hours, which is prohibitively long in many settings, such as on-scanner calculation for clinical applications. Here, we present a fast approach for the decomposition of multi-exponential signals. The method is applied to multi echo spin echo MRI scans and computes myelin water maps of the whole brain in under 2 min, and luminal water maps of the prostate in under 1 min.