Tissue biology perspective on macrophages

被引：497

作者：

Okabe, Yasutaka ^{[1
]}

Medzhitov, Ruslan ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Immunobiol, New Haven, CT 06510 USA

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ALVEOLAR MACROPHAGES; GENE-EXPRESSION; NEURAL CREST; SPI-C; INFLAMMATION; DIFFERENTIATION; INDUCTION; DIVERSITY; CELLS; HETEROGENEITY;

D O I：

10.1038/ni.3320

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophages are essential components of mammalian tissues. Although historically known mainly for their function in host defense and the clearance of apoptotic cells, macrophages are now increasingly recognized as serving many roles in tissue development, homeostasis and repair. In addition, tissue-resident macrophages have many tissue-specific functional characteristics, which are a reflection of distinct gene-expression programs. Here we discuss the emerging views of macrophage biology from evolutionary, developmental and homeostatic perspectives.

引用

页码：9 / 17

页数：9

共 82 条

[31] The immune system in atherosclerosis [J].

Hansson, Goran K. ;

Hermansson, Andreas .

NATURE IMMUNOLOGY, 2011, 12 (03) :204-212

[32]

Hickman C.P., 2009, INTEGRATED PRINCIPLE

[33] Alveolar macrophages: plasticity in a tissue-specific context [J].

Hussell, Tracy ;

Bell, Thomas J. .

NATURE REVIEWS IMMUNOLOGY, 2014, 14 (02) :81-93

[34] Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation [J].

Ip, W. K. Eddie ;

Medzhitov, Ruslan .

NATURE COMMUNICATIONS, 2015, 6

[35] Conditional ablation of LYVE-1+cells unveils defensive roles of lymphatic vessels in intestine and lymph nodes [J].

Jang, Jeon Yeob ;

Koh, Young Jun ;

Lee, Seung-Hun ;

Lee, Junyeop ;

Kim, Kyoo Hyun ;

Kim, Daesoo ;

Koh, Gou Young ;

Yoo, Ook Joon .

BLOOD, 2013, 122 (13) :2151-2161

[36] Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions [J].

Kashio, Makiko ;

Sokabe, Takaaki ;

Shintaku, Kenji ;

Uematsu, Takayuki ;

Fukuta, Naomi ;

Kobayashi, Noritada ;

Mori, Yasuo ;

Tominaga, Makoto .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (17) :6745-6750

[37] Induction of the neural crest: A multigene process [J].

Knecht, AK ;

Bronner-Fraser, M .

NATURE REVIEWS GENETICS, 2002, 3 (06) :453-461

[38] Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis [J].

Kohyama, Masako ;

Ise, Wataru ;

Edelson, Brian T. ;

Wilker, Peter R. ;

Hildner, Kai ;

Mejia, Carlo ;

Frazier, William A. ;

Murphy, Theresa L. ;

Murphy, Kenneth M. .

NATURE, 2009, 457 (7227) :318-321

[39] Homeostasis, Inflammation, and Disease Susceptibility [J].

Kotas, Maya E. ;

Medzhitov, Ruslan .

CELL, 2015, 160 (05) :816-827

[40] Mechanisms and Functions of Inflammasomes [J].

Lamkanfi, Mohamed ;

Dixit, Vishva M. .

CELL, 2014, 157 (05) :1013-1022

← 1 2 3 4 5 6 7 8 9 →