Dendrigraft of Poly-L-lysine as a Promising Candidate To Reverse Heparin-based Anticoagulants in Clinical Settings

被引：17

作者：

Ourri, Benjamin ^{[1
]}

Francoia, Jean-Patrick ^{[2
]}

Monard, Gerald ^{[3
]}

Gris, Jean-Christophe ^{[4
,5
]}

Leclaire, Julien ^{[1
]}

Vial, Laurent ^{[1
,2
]}

机构：

[1] Univ Claude Bernard Lyon 1, Univ Lyon, ICBMS, CNRS,UMR 5246, 43 Blvd 11 Novembre 1918, F-69622 Villeurbanne, France

[2] Univ Montpellier, CNRS, UMR 5247, IBMM, Pl Eugene Bataillon, F-34296 Montpellier 5, France

[3] Univ Lorraine, CNRS, UMR 7019, LPCT, Blvd Aiguillettes,BP 70239, F-54506 Vandoeuvre Les Nancy, France

[4] Univ Montpellier, Univ Nimes Hosp, Dept Hematol, F-30029 Nimes 9, France

[5] First IM Sechenov Moscow State Med Univ, Moscow 119146, Russia

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2019年 / 10卷 / 06期

关键词：

Anticoagulant; antidote; heparin; dendrigraft of poly-L-lysine; protamine; SUPRAMOLECULAR CHEMISTRY; PROTAMINE; BINDING; FONDAPARINUX; COMPLEX; ASSAY;

D O I：

10.1021/acsmedchemlett.9b00090

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

By using a combination of experimental and computational experiments, we demonstrated that a second-generation dendrigraft of poly-L-lysine neutralizes the anticoagulant activity of unfractionated heparin, low-molecular-weight heparin, and fondaparinux more efficiently than protamine does in human plasma, making this synthetic polymer a promising surrogate of this problematic protein in clinical settings.

引用

页码：917 / 922

页数：11

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