The antidepressant-like effects of topiramate alone or combined with 17β-estradiol in ovariectomized Wistar rats submitted to the forced swimming test

被引:7
|
作者
Molina-Hernandez, Miguel [1 ]
Patricia Tellez-Alcantara, N. [1 ]
Olivera-Lopez, Jorge I. [2 ]
Teresa Jaramillo, M. [2 ]
机构
[1] Univ Veracruzana, Inst Invest Psicol, Lab Psicobiol & Etol, Jalapa, Veracruz, Mexico
[2] Univ Autonoma Metropolitana, Div Ciencias Salud, Mexico City, DF, Mexico
关键词
Antidepressants; Topiramate; Forced swimming test; 17; beta-estradiol; SEROTONIN REUPTAKE INHIBITORS; OLFACTORY-BULBECTOMIZED RAT; 17-BETA ESTRADIOL; MAJOR DEPRESSION; SEX-DIFFERENCES; FEMALE RATS; STEROID-HORMONES; 5-HT1A RECEPTOR; NEUROPEPTIDE-Y; ESTROUS-CYCLE;
D O I
10.1007/s00213-013-3251-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
There is a significant delay in the clinical response of antidepressant drugs, and antidepressant treatments produce side effects. We examined the relationship between 17 beta-estradiol and topiramate in ovariectomized Wistar rats submitted to the forced swimming test (FST). Topiramate was administered alone or combined with 17 beta-estradiol to ovariectomized rats submitted to the FST. Topiramate (20 mg/kg, P < 0.05; 30 mg/kg, P < 0.05) reduced immobility by increasing swimming; these effects were antagonized by finasteride (50 mg/kg). In interaction experiments, topiramate (10 mg/kg) plus 17 beta-estradiol (5 micrograms per rat; P < 0.05) reduced immobility by increasing swimming behavior. Besides, 17 beta-estradiol (2.5 micrograms per rat) shortened the onset of the antidepressant-like effects of topiramate (P < 0.05). In the open field test, topiramate alone or combined with 17 beta-estradiol (P < 0.05) reduced locomotion. Topiramate alone or combined with 17 beta-estradiol produced antidepressant-like actions; and 17 beta-estradiol shortened the onset of the antidepressant-like effects of topiramate.
引用
收藏
页码:3343 / 3350
页数:8
相关论文
共 50 条
  • [1] The antidepressant-like effects of topiramate alone or combined with 17β-estradiol in ovariectomized Wistar rats submitted to the forced swimming test
    Miguel Molina-Hernández
    N. Patricia Téllez-Alcántara
    Jorge I. Olivera-López
    M. Teresa Jaramillo
    Psychopharmacology, 2014, 231 : 3343 - 3350
  • [2] The folic acid combined with 17-β estradiol produces antidepressant-like actions in ovariectomized rats forced to swim
    Molina-Hernandez, Miguel
    Patricia Tellez-Alcantara, N.
    Olivera-Lopez, Jorge I.
    Teresa Jaramillo, M.
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2011, 35 (01): : 60 - 66
  • [3] Nicotine and 17β-estradiol produce an antidepressant-like effect in female ovariectomized rats
    Kandi, P.
    Hayslett, R. L.
    BRAIN RESEARCH BULLETIN, 2011, 84 (03) : 224 - 228
  • [4] Dopamine is involved in the antidepressant-like effect of allopregnanolone in the forced swimming test in female rats
    D'Aquila, Paolo S.
    Canu, Silvia
    Sardella, Marco
    Spanu, Caterina
    Serra, Gino
    Franconi, Flavia
    BEHAVIOURAL PHARMACOLOGY, 2010, 21 (01): : 21 - 28
  • [5] Orally administered whole egg demonstrates antidepressant-like effects in the forced swimming test on rats
    Nagasawa, Mao
    Otsuka, Tsuyoshi
    Ogino, Yumi
    Yoshida, Junki
    Tomonaga, Shozo
    Yasuo, Shinobu
    Furuse, Mitsuhiro
    ACTA NEUROPSYCHIATRICA, 2014, 26 (04): : 209 - 217
  • [6] Antidepressant-like effect of different estrogenic compounds in the forced swimming test
    Estrada-Camarena, E
    Fernández-Guasti, A
    López-Rubalcava, C
    NEUROPSYCHOPHARMACOLOGY, 2003, 28 (05) : 830 - 838
  • [7] Orchiectomy modifies the antidepressant-like response of nicotine in the forced swimming test
    Bonilla-Jaime, H.
    Limon-Morales, O.
    Arteaga-Silva, M.
    Hernandez-Gonzalez, M.
    Guadarrama-Cruz, G.
    Alarcon-Aguilar, F.
    Vazquez-Palacios, G.
    PHYSIOLOGY & BEHAVIOR, 2010, 101 (04) : 456 - 461
  • [8] Potentiation of the antidepressant-like effect of desipramine or reboxetine by metyrapone in the forced swimming test in rats
    Rogoz, Zofia
    PHARMACOLOGICAL REPORTS, 2009, 61 (06) : 1173 - 1178
  • [9] EFFECTS OF ANTHOCYANINS AND ESTRADIOL IN FORCED-SWIMMING TEST OF OVARIECTOMIZED RATS
    Varadinova, Miroslava
    Drenska, Diana
    Boyadjieva, Nadka
    COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, 2010, 63 (07): : 1061 - 1066
  • [10] Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats
    Heiberg, IL
    Wegener, G
    Rosenberg, R
    BEHAVIOURAL BRAIN RESEARCH, 2002, 134 (1-2) : 479 - 484